Primobolan side effects is a selective agonist of beta2-adrenergic receptors. At therapeutic doses it acts on beta2-adrenergic receptors of smooth muscles of the bronchi, providing pronounced bronchodilator effect, prevents and relieves bronchospasm, increases lung capacity. It prevents the release of histamine, slow reacting substances from mast cells and neutrophil chemotactic factors. It is a small positive chrono-and inotropic effect on the myocardium, expansion of coronary artery, practically does not reduce blood pressure. Has tocolytic effect: it lowers the tone and contractile activity of the myometrium. The drug starts 5 minutes after inhalation and lasts for 4-6 hours. It has a number of metabolic effects: reduces the content of K + in the plasma affects glycogenolysis and insulin release, has a hyperglycemic (especially in asthmatic patients) and lipolytic effect, increases the risk of acidosis.
Pharmacokinetics After inhalation of 10 to 20% of the dose enters the respiratory tract. The rest of the unit is delayed or is deposited in the oropharynx and then swallowed. Portion of the dose that has remained in the respiratory tract, is absorbed by lung tissues without being metabolized in the lungs, and into the bloodstream. When injected into the blood system, it can be metabolized in the liver and excreted primarily in the urine in unchanged form or in the form of phenolic sulphate. Part of the dose received by 4-chlorodehydromethyltestosterone the gastro-intestinal tract, is absorbed and is extensively metabolized during the first pass through the liver, turning into phenol sulfate. Unchanged drug and conjugate are derived mainly from the urine. Most of the dose of primobolan side effects administered intravenously, orally or by inhalation, is displayed for 72 hours.The degree of primobolan side effects binding to plasma proteins is 10%. Maximum plasma concentration – 30 ng / ml. The half – 3.7 to 5 hours.
Indications Prevention and relief of bronchospasm in bronchial asthma, chronic obstructive bronchitis, emphysema.
Contraindications: hypersensitivity to any component of the drug, arrhythmias (paroxysmal tachycardia, ventricular arrythmia politopnye), myocarditis, heart defects, aortic stenosis, coronary heart disease, hypertension, heart diabetes, glaucoma, seizures, which pilorodoudenalnoe narrowing, renal or hepatic insufficiency, pregnancy, concomitant use of nonselective beta-blockers, children up to 2 years. With care – heart failure, hyperthyroidism.
Pregnancy and lactation . Contraindicated during pregnancy
The lactation appointed only in cases where the expected benefit to the mother outweighs any possible risk to the child.
Dosage and administration Adults and children over 12 years: 100-200 mcg Astalina (1-2 inhalation doses) for the relief of asthma attacks. To control primobolan half life the flow of mild asthma – 1-2 dose 1-4 times a day and an average disease severity – at the same dosage in combination with other antiasthmatic agents. To prevent asthma physical effort – for 20-30 minutes before loading dose of 1-2 at the reception. Children from 2 to 12 years: With the development of bronchial asthma attack, and to prevent attacks of asthma associated with exposure to the allergen or exercise-induced, the recommended dose is 100-200 mg (1 or 2 inhalations). The daily dose of primobolan side effects should not exceed 1200 mcg (12 inhalations).
Side effects Astalin can cause tremors of fingers, which is a typical side effect of agonists beta2-adrenergic receptors. There may be headache, dizziness, irritability, anxiety, sleep disorder, insomnia, increased peripheral vascular (flushing of skin), small compensatory increase in heart rate, increased blood pressure. May develop hypersensitivity reactions (including angioedema, urticaria, erythema, nasal congestion, bronchospasm, hypotension and collapse); muscle cramps, nausea, vomiting, dyspepsia. Inhaled medicines may cause paradoxical bronchospasm. Inhaled medicines may cause irritation of the mucous membranes of the mouth and pharynx (throat), coughing. Therapy primobolan side effects may cause hypokalemia, which may pose a serious danger to the patient, as well as reversible metabolic disorders, such as an increase in the concentration of glucose in blood. The drug can cause excitement and increase motor activity in children. Perhaps the appearance of arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystoles).
Overdosing Symptoms: nausea, vomiting, irritability, hallucinations, tachycardia, ventricular flutter, the expansion of peripheral blood vessels, lowering blood pressure, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscle tremor, headache. Treatment: removal of preparation, cardioselective beta-blockers; symptomatic therapy. If you suspect an overdose should monitor the level of potassium in the blood serum.
Interaction with other drugs Theophylline and other xanthine, while the use of primobolan side effects increases the risk of tachyarrhythmias; means for inhalation anesthesia, levodopa -. severe ventricular arrhythmias is not recommended to simultaneously use Astalin and non-selective beta-adrenoceptor blockers, such as propranolol. Monoamine oxidase inhibitors, and tricyclic antidepressants increase the effect of primobolan side effects and may lead to a sharp decrease in pressure. primobolan side effects increases the effects of central nervous system stimulants, kardiotropnyh thyroid hormone, increases the risk of glycoside intoxication.Reduces the effectiveness of antihypertensive drugs and nitrates. Hypokalemia may be enhanced by the simultaneous use of xanthine derivatives, glucocorticoids, diuretics. Co-administration of anticholinergic drugs pronabolin side effects (including inhalants) can increase intraocular pressure.
Cautions In patients with severe or unstable over asthma use of bronchodilators should not be the primary or only method of treatment. If the action of the usual dose Astalina becomes less effective or less long (effect of the drug should be kept at least 3 hours), the patient should see a doctor. Frequent use of primobolan side effects may exacerbate bronchospasm, sudden death, and therefore between taking regular doses of the drug to take breaks in a few hours. Increasing demand for the use of inhaled beta2-adrenergic agonists with a short duration of action for the control of asthma symptoms indicative of an exacerbation of the disease. In such cases, you should review the patient’s treatment plan and decide on the appointment or increasing the dose of inhaled or systemic steroids glyukokortiko. Therapy agonists beta2-adrenergic receptors may lead to hypokalemia. It advised to exercise special care when treating severe asthma attacks, since in these cases, hypokalemia may be enhanced by the simultaneous use of xanthine derivatives, corticosteroids, diuretics, and also due to hypoxia. In such situations it is necessary to control the potassium level in the blood serum. oral steroids for muscle building eu pharmaceuticals reviews buy steroid cream online steroid purchase online oxydine buy steroids online
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