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Pharmacological properties : Pharmacodynamics: combined drug, has a bronchodilator, expectorant and mucolytic action. primobolan – bronchodilator, stimulates beta2-adrenergic receptors of the bronchi, blood vessels and myometrium. It prevents or eliminates bronchospasm, reduces the resistance in the airways, increasing lung capacity. It is an extension of the coronary arteries, it does not reduce blood pressure. Bromhexinum -mukoliticheskoe means, has expectorant and antitussive effect. Increases serous component of bronchial secretions; activates the cilia of ciliated epithelium, reduces the viscosity of mucus, increases its volume and improves expectoration. Gvayfenezin – mucolytic tool that reduces the surface tension structures bronchopulmonary apparatus; It stimulates the secretory cells of the bronchial mucosa, producing neutral polysaccharides depolymerized acid mucopolysaccharides, reduces the viscosity of phlegm, activates the ciliary apparatus of the bronchi, facilitates the removal of phlegm and promotes the transformation of non-productive cough productive.Pharmacokinetics primobolan: ingestion absorption – high. Food intake reduces the absorption rate, but does not affect the bioavailability. Communication with plasma proteins – 10%. It crosses the placenta. Treated first-pass metabolism in the liver and intestinal wall fenolsulfotransferazy inactivated by up to 4-O-sulfate ester. The half-life (T1 / 2) -. 3.8-6 hours excreted by the kidneys (69-90%), mainly as an inactive metabolite fenolsulfatnogo (60%) for 72 hours and in the bile (4%). Bioavailability of orally administered primobolan is about 50%. Bromhexine: ingestion almost completely (99%) absorbed in the gastrointestinal tract (GIT) for 30 min. Bioavailability – low (primary effect “pass” through the liver). It penetrates through the placental and blood-brain barriers. The liver is demethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T 1/2 -15 hours (due to the slow diffusion of the back fabric). Excreted by the kidneys. In chronic renal failure, impaired excretion of metabolites. Repeated use can cumulate. Gvayfenezin: absorption from the gastrointestinal tract – fast (25-30 min after ingestion). T 1/2 -1ch. Into tissues containing mucopolysaccharides acidic. Approximately 60% of the administered drug is metabolized in the liver. Light output (sputum) and kidneys in unchanged form and as inactive metabolites.

Indications for use
primobolan injectionin combination therapy of acute and chronic bronchopulmonary diseases associated with the formation of difficult to separate the viscous secretions:
– asthma,
– bronchitis,
– obstructive bronchitis,
– pneumonia,
– emphysema;
– whooping cough;
– pneumoconiosis;
– tuberculosis of the lungs and al.

– Hypersensitivity to the drug;
– pregnancy, lactation;
– tachyarrhythmia, myocarditis
– heart diseases;
– Decompensated diabetes mellitus,
– hyperthyroidism,
– glaucoma
– hepatic or renal failure
– gastric ulcer and duodenal ulcer in the acute stage ;
– gastric bleeding;
– hypertension;
– children up to age 6 years.

Be wary appoint patients with diabetes, gastric ulcer and duodenal ulcer in remission.

Pregnancy and lactation
During pregnancy, drug use is not recommended.
Breastfeeding should be discontinued if necessary drug treatment during lactation.

Dosing and Administration
Inside. Adults and children over 12 years: 1 tablet 3 times / day.
Children under the age of 6 years to 12 years -. 1/2 or 1 tablet 3 times / day
Children under 6 years of age is recommended to use the syrup “Ascoril expectorant” .

Side effect
Rare: when used in high doses can sometimes occur headache, dizziness, increased nervous irritability, insomnia, somnolence, tremor, convulsions, nausea, vomiting, diarrhea, exacerbation of gastric ulcer and duodenal ulcers, heart palpitations, possibly staining of urine pink, allergic reactions (rash, urticaria), collapse, bronchospasm.

Overdosing Symptoms: increased manifestations of side effects. Treatment: symptomatic therapy.

Interaction with other medicinal products
Other beta-2 Adrenomimeticalkie funds and theophylline increases the effects of primobolan and increase the likelihood of side effects.
Ascoril not appointed concurrently with drugs containing codeine and other antitussive, as it is difficult expectoration of liquefied sputum.
Part of the drug Ascoril bromhexine facilitates the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) in the lung tissue.
It is not recommended to use Ascoril drug simultaneously with non-selective beta-adrenoceptor blockers, such as propranolol.
part of the preparation Ascoril primobolan are not recommended for patients who receive inhibitors of monoamine oxidase (MAO ).
Diuretics drugs and corticosteroids enhance the hypokalemic effect of primobolan.
It is not recommended to take in conjunction with Ascoril alkaline water.